Abstract Search

ea0031p291 | Pituitary | SFEBES2013

Is diethylstilboestrol an endocrine disruptor in the developing human fetal testis? Effects of DES exposure using a xenograft approach

Mitchell R T , Anderson R A , van den Driesche S , McKinnell C , MacPherson S , Wallace W H B , Kelnar C J H , Sharpe R M

Context: In rodents, in-utero exposure to the exogenous oestrogen diethylstilboestrol (DES) results in reproductive abnormalities in male offspring. It has been proposed that similar anti-androgenic effects also occur in the human fetal testis following oestrogen exposure.Objective: Determine effects of DES exposure on testosterone production by normally growing human fetal testis xenografts.Design: Human fetal testes (15&...

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ea0023p23 | (1) | BSPED2009

The Androgen Status Of Young Women With Premature Ovarian Failure Depends On The Female Sex Steroid Replacement Regimen

Mason A , Wallace M A , MacIntyre H , Teoh P Y , Bath L E , Critchley H O , Kelnar C J H , Wallace H W B , Ahmed S F

Aims: To compare the effect of a standard Sex Steroid Regimen (sSSR) with a physiological SSR (pSSR) on androgen status in young women with premature ovarian failure (POF).Patient Population: Seven women with POF were evaluated for the study. The median age was 28 years (range 2136) and the median duration of ovarian failure was 14 years (range 425).Methods: An open label randomised, controlled, crossover study over 28 ...

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Endocrine Abstracts

Is diethylstilboestrol an endocrine disruptor in the developing human fetal testis? Effects of DES exposure using a xenograft approach

The Androgen Status Of Young Women With Premature Ovarian Failure Depends On The Female Sex Steroid Replacement Regimen

BiosciAbstracts